BLOG DISCLAIMER

**DISCLAIMER** Please note: I am not a veterinarian, and the purpose of this blog is solely to educate, provide resources, and share Reo's story. In this blog, I will present research and information on the theories of SARDS to which I subscribe, along with my own narrative. If you think your dog may have SARDS, or adrenal exhaustion/Plechner Syndrome, please seek veterinary care right away!

If you are just beginning your SARDS education, I suggest you start with the blog post from August 22, 2011 entitled "SARDS Resources". If you'd like to know our trials, tribulations, and joys from the beginning, start with "But first...Reo!" and click chronologically on from there.

If you would like to read my suggestions as to how I would approach treatment for a newly-diagnosed dog, check the November 16, 2011 post "If I had another SARDS dog" (and then read my blog more fully for appropriate context).

Though we have decided to suspend Reo's retinal protection supplements in September 2012 (see September 16, 2012 post "Decision for Reo") due to the fact that she had very little remaining vision, I am still strongly supportive of our treatment approach, and know that it changed Reo's health and longevity in a positive way. Feel free to comment and ask me any questions - I am happy to help if I can!

Update: Reo became an angel on October 21, 2014. She had a profound kidney infection, causing acute kidney failure, and she was unable to recover. The contributing factors to her decline are covered in my February 16, 2015 blog post "Farewell to Reo".

Though I do not regularly update this blog any longer, much of the information is still relevant (though some of the links may be out of date). Feel free to join the conversation at "SARDS Dogs United" on Facebook.




Monday, October 31, 2011

Happy Howl-o-ween!

Happy Halloween!! 

from Reo, the punk rocker!



ANARCHYYYYYY (or dog treats!!)





And, also, from Leigh the butterfly:




And Tula the Doberman:


"Yes, I am dressed as a squirrel...what of it??"

Hope you and your pups all have a very safe holiday!

Friday, October 28, 2011

Back and Forth...

10/28/11 - Happy Friday!  I am looking forward to the weekend.  Fall has definitely fallen, and there are a lot of leaves to be raked!  I hope that it's sunny this weekend, so we can all be outside while we pick up nature's lovely, colorful mess.

Reo has been doing okay this week.  Her vision is definitely variable, which frustrates me.  Sometimes it's like she can't see anything at all, and other times, she seems to be at ~80% or so.  It's strange to me how it can change in a matter of minutes - makes me wonder what the heck is going on in that retina!  I usually know when she's not seeing because she will use her nose more to sniff around to help find her way.  Her vision remains quite good outside or in bright lighting.

Mood-wise, she is fantastic.  I know I've said this before, but she hasn't acted this spritely in a couple of years, so to see her so playful and happy is truly amazing.  Sean always says that this is the most important part (and I do agree...I just want some of her vision to stay, too!).  We most certainly have our dog back, in terms of her personality!

All of her "functions" have been normal, too, which is good.  I have noticed the past two mornings, she's gotten up earlier than normal, and has panted a few times under the covers in bed.  This usually makes me question her estrogen levels, as this was a primary symptom in January/February this year (she couldn't tolerate sleeping under the covers without panting, whereas pre-hormonal imbalance she'd just be a little briquet under the covers till morning).  So, panting makes me think of the heat intolerance that comes with high estrogen levels.  On the other hand, I'm a really hot sleeper - in the winter, I like the temperature to be around 58 in the house (for sleeping, not during the day!) and all warm and snuggly under the covers.  So lately, I've been warm since the house is in the 60s, which is hopefully why Reo has been panting on occasion (which is ameliorated by my bringing her up on top of the covers).

Reo seems to tolerate the lutein supplement quite well.  I haven't noticed any changes, either good or bad.  I think I'll just keep her on the every other day dose for the time being.  She has plenty of antioxidants from the Cell Advance - the lutein is just an added one to hopefully help protect those valuable retinal cells.

However, I decided to take her off the Vetri-DMG liquid in the next week or so, as Reo's last CBC revealed that her liver enzymes were in good shape (and as her hormone levels become more balanced, this will make her liver happier as well).  The Vetri-DMG also stimulates the immune system, and I don't want *too* many immune system stimulants going on.  I'd like to cut down supplements where I can, as I don't want her to be a science experiment forever!  Dr. Lanz uses the Vetri-DMG for liver and immune support, but Reo is doing well in both of those areas at the moment, so it's safe to stop.

Monday, October 24, 2011

Tricks or treats? TREATS!

10/24/11 - We had a nice fall weekend!  Friday night I took Reo and Leigh for a nice long walk (while Sean took Tula to the dog park).  It was sunny, and neither too cold nor too hot for walking - the best!

Earlier in the week, I cooked a rabbit for all the dogs.  This was a special treat that I used as a meal topper.  All three of our dogs have a penchant for chasing rabbits, so I was sure they'd enjoy the meat!  That they did, for sure.  They all tolerated it very well, too - no loose stools.

Saturday was a house project kind of a day, and Reo was very involved in the supervision of all tasks.  I had to go to the store to pick up a few things, and on a whim got some doggie costumes for Halloween.  I haven't taken any pictures yet, but I will post them up on this blog for all to enjoy!

Sunday, Reo's stomach aliens came back, so she refused breakfast.  As usual, there seems to be no rhyme or reason to the aliens.  I had to force down her morning hormone meds, and around noon or so, she started feeling better.  She got a small meal in the early afternoon, and ate all of her dinner!

I noticed that the skin on Reo's stomach (mostly on her sides toward her back legs) is really dark.  I know that darkened skin is a symptom of increased estrogen levels, which isn't great news.  On the other hand, a lot of her chest hair is growing back.  Hopefully the two symptoms counteract each other, and her estrogen levels are okay.  Planning to get another EI-1 panel in December...

I cooked up some organic chicken thighs for the dogs' meal topper this week.  As a bonus, Sean and I had a whole chicken for dinner, so the dogs got the gizzards from that chicken in with their thigh meat!  Tasty for them.  I've also scaled back the food amounts on all the dogs. With the cooler temperatures, it means less walking, which means ounces gained for both dogs and humans!

Wednesday, October 19, 2011

Autumn sassy time

10/19/11 - Yesterday, I got home from work and promptly took all the dogs out for a walk.  It was a little chilly, a little breezy, and the squirrels were busy hiding acorns for winter!  There is a big acorn tree two houses down from us, and the cars parked underneath are constantly bombarded by falling acorns - it's amazing the cars aren't dented!

Anyway, all the dogs were feeling so spirited, it made me laugh just to watch them.  I grew up with horses, and fall was always the most fun time to ride because the horses were so spirited and sassy - just full of themselves!  This is how our dogs were acting yesterday.  Reo was in her full-on "stalker" run.  She has a special way of trotting along when she's "hunting" for squirrels.  She gets lower to the ground and takes longer strides (as opposed to her normal min pin hackney).  It made for a fun, brisk walk.

This morning it was the coldest it's been so far since the summer, with a little rain to boot, so none of the dogs was interested in being outside for a second longer than needed!  They did their morning business and then ran back, shivering!  Reo, being Reo, was feeling sassy and so promptly attacked two of her toys after coming inside while she waited (not-so-patiently!) for breakfast.

Fall is in the air!

Monday, October 17, 2011

Lutein and why I'm using it

10/17/11 - Today,  I received the Source Naturals Lutein supplement in the mail (thanks Amazon.com!).  I opened it up, and saw small, pretty purpley colored capsules.  I opened up a capsule and tasted the supplement, and was delighted that it was not bitter in the least - it has a slightly sweet flavor.  This means that it will be palatable to Reo (who is on the edge already with the bitter-tasting Cell Advance and Phosphatidyl Serine in her meals).

It appears that lutein is well-tolerated by dogs, but for now my plan is to start out with the supplement every other day to see how she tolerates it.  In this paper:  Dietary lutein stimulates immune response in the canine, 25-lb beagles were given daily amounts of lutein in either 5, 10, or 20 mg dosages.  The paper didn't cite any adverse effects, and it appears that it took about 2 weeks for the beagles' serum lutein levels to increase.  I'll see how Reo does on the 6 mg dosage every other day for a couple of weeks, and then potentially increase to daily.

Why the heck am I giving Reo another supplement, you ask?  (It's okay if you asked that...Sean asked too!)  I decided to supplement the lutein based on these two studies (as well as the regularly available information that lutein is good for eyes in general, people too!):

If you've read Caroline Levin's position on SARDS, you might remember that she states that vision loss occurs due to mitochondrial damage in the retinal cells due to the uptake of calcium (which happens as a result of increased estrogen levels).  

It appears that the energy-dependent uptake of calcium ions by the mitochondria is inhibited by lutein, which also helps to efflux (pump out) calcium ions from mitochondria, as this paper states.  So you might think that if there is enough lutein present in the eye, it would help prevent the uptake of calcium if estrogen levels are high.

As well, this paper asserts that lutein and its isomer zeaxanthan help to prevent the apoptosis (killing of cells) of photoreceptor cells in the retina, through their antioxidant properties.

You can read more about lutein on Wikipedia.  There are also rich dietary sources of lutein, if you are cooking for your dog!  Cooked kale and cooked spinach are both naturally very high in lutein, so these would be good choices to put in your dog's veggie mix!

Reo ate up her dinner lickety-split, so we are underway!

Sunday, October 16, 2011

Eye supplement comparison chart


10/16/11 - Many people out there give their SARDS dog some sort of supplement to help protect the dog's retinal cells from further damage.  I was trying to figure out what would be the best to give Reo, so I made a simple table to compare some of the more common supplements.  The cost basis and dosages were based on the "small dog" side of things, so ingredient analysis and cost will be different for larger dogs.

Please note the abbreviations mg (milligrams), mcg (micrograms), and IU (international units). NA means not available/not listed as an ingredient.

Apologies for the rendering in this blog - I couldn't quite get the whole table to fit, and didn't want the text to be too small!  I do have this in an Excel spreadsheet.  If anyone would like a copy, just post a comment with your email, and I will send it on over!


Cell Advance 440
Ocu-Glo RX (small dog)
Nutri-Vet Healthy Vision Chewables
Source Naturals Lutein 6 mg capsules
Ocuvite Lutein Eye
Ocuvite Eye
Icaps Lutein and Omega3
Vitamin C
250 mg
50 mg
75 mg
NA
60 mg
200 mg
45 mg
Vitamin E
37.5 IU
25 IU
20 IU
NA
30 IU
60 IU
10 IU
Vitamin B6
6.25 mg
0.1 mg
NA
NA
NA
NA
1.3 mg
Zinc
3.75 mg
3 mg
5 mg
NA
15 mg
40 mg
7 mg
Coenzyme Q10
1.25 mg
13 mg
NA
NA
NA
NA
NA
Biotin
NA
10 mcg
NA
NA
NA
NA
NA
Panthothenic Acid
NA
1 mg
NA
NA
NA
NA
NA
Vitamin B1
NA
0.1 mg
NA
NA
NA
NA
1.2 mg
Vitamin B3
NA
1.2 mg
NA
NA
NA
NA
16 mg
Alpha Lipoic Acid
NA
35 mg
NA
NA
NA
NA
NA
Lycopene
NA
1 mg
NA
NA
NA
NA
NA
Green Tea Extract
NA
20 mg
NA
NA
NA
NA
NA
Folate/Folic Acid
NA
20 mcg
NA
NA
NA
NA
240 mcg
Vitamin B12
NA
2.5 mcg
3 mcg
NA
NA
NA
2.4 mcg
Beta carotene
1,875 IU
NA
NA
NA
NA
NA
NA
Vitamin A
1,250 IU
NA
1,000 IU
NA
NA
1,000 IU
600 mcg
Methionine
12.5 mg
NA
NA
NA
NA
NA
NA
L-cysteine
12.5 mg
NA
NA
NA
NA
NA
NA
L-glutathione
12.5 mg
NA
NA
NA
NA
NA
NA
Magnesium
9.8 mg
NA
NA
NA
NA
NA
NA
L-lysine
6.25 mg
NA
NA
NA
NA
NA
NA
Hesperidin
5 mg
NA
NA
NA
NA
NA
NA
Rutin
5 mg
NA
NA
NA
NA
NA
NA
Catalase
10 mg
NA
NA
NA
NA
NA
NA
Super Oxide Dismutase
2.75 mg
NA
NA
NA
NA
NA
NA
Quercetin
2.5 mg
NA
NA
NA
NA
NA
NA
Manganese
0.25 mg
NA
NA
NA
NA
NA
2.3 mg
Copper
62.5 mcg
NA
4 mcg
NA
2 mg
2 mg
0.9 mcg
Selenium
125 mcg
NA
3 mcg
NA
NA
55 mcg
34 mcg
Molybdenum
6.3 mcg
NA
NA
NA
NA
NA
NA
Vitamin B2
NA
NA
4 mg
NA
NA
NA
1.3 mg
Grapeseed Extract
NA
yes
5 mg
NA
NA
NA
NA
Lutein
NA
yes
5 mg
6 mg
6 mg
2 mg
10 mg
Bilberry Extract
NA
NA
4 mg
NA
NA
NA
NA
Zeaxanthan
NA
NA
80 mcg
300 mcg
NA
NA
2 mg
Other Ingredients
Gelatin exterior capsule
Gelatin, Glycerin, Beeswax, Lecithin, Soybean Oil and Liver Extract
Beef Liver, Magnesium Silicate, Magnesium Stearate, Natural Pork Flavor, Plant Cellulose, Pork Liver, Silicon Dioxide, Stearic Acid, Sucralose
FloraGLO Marigold flower extract, red beet root, gelatin (capsule), maltodextrin, magnesium sterate, and silica
Lactose monohydrate, Crospovidone, Magnesium Stearate, Silicon dioxide

Calcium, Omega-3 fatty acids, others not listed








Approx. cost/day
$0.24
$0.78
$0.21
$0.12
$0.31
$0.12
$0.29


Based on my research, for Reo, I am going to keep her on the Cell Advance 440, but also supplement the Source Naturals 6 mg Lutein and zeaxanthan. I like all of the powerful antioxidants that are in the Cell Advance, as it will not only help protect Reo's retinal cells, but also with her immune system support. On
the other hand, I think it's valuable to have some lutein and zeaxanthan in the mix, too, because there is quite a bit of published research on the positive effect of both compounds in the eye.  Since this is lacking in Cell Advance, I'm going to try supplementing the Source Naturals Lutein and see if I notice any changes.

The Ocu-GLO looks good, but it seems fairly expensive relative to the other supplements/ingredients, which is why I decided to mix and match.

So, at the very least, it was a useful exercise for me! :)  Hopefully someone else will find it useful as well!