tag:blogger.com,1999:blog-39411848396672022152024-03-05T04:45:10.015-08:00A journey with SARDS - from despair to a cure!In March 2011, our Miniature Pinscher, Reo, suddenly went blind and was diagnosed with SARDS (Sudden Acquired Retinal Degeneration Syndrome). We were given no hope for vision recovery, but through research, perseverance, love, tears, and a lot of luck, we brought our dog back from a serious illness, and restored some functional vision in about 5 months! This is our story, our journey...and we hope that by sharing our story, we can help other dogs diagnosed with SARDS!Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.comBlogger130125tag:blogger.com,1999:blog-3941184839667202215.post-16453590743044377172016-01-19T07:51:00.002-08:002020-02-18T08:05:21.799-08:00Update on Caroline Levin's consultationsJanuary, 2016<br />
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Hello, everyone! I wanted to write a quick update and let my readers know that Caroline Levin is no longer doing personalized consultations for new SARDS dog owners. After about a decade of doing these consultations, it's a huge loss to our SARDS community. :( Caroline was an advocate for manny of us (and our dogs, of course!). I, personally, appreciated Caroline's knowledge, patience, and her wonderful "bedside" manner. I know many others feel the same.<br />
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The good news is, her protocol is published in her book "Living With Blind Dogs" (which is an excellent book, even if you choose not to pursue treatment for your dog!). She is also willing to send an information packet to people for a nominal fee.<br />
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This packet of info includes an overview of the problem/treatment with case statistics, where to send the lab work, how to interpret the lab work, the most up-to-date version of the protocol with easily formatted medication dosages, where to find various products/supplements, an endorsement from a Florida vet, and how to find a vet if yours won’t help you.<br />
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You may still reach Caroline through her website: <a href="https://petcarebooks.com/product/sard-treatment-files/">https://petcarebooks.com/product/sard-treatment-files/</a><br />
<br />Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com8tag:blogger.com,1999:blog-3941184839667202215.post-65688915188454546112015-02-16T12:17:00.000-08:002015-02-16T12:22:32.537-08:00Farewell to Reo<h2>
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Thanks, everyone for your comments, messages, and thoughts in the wake of Reo's passing. We still miss her every day - some more than others. I know she is with us all of the time, and she occasionally will "possess" one of our other Min Pins, which always makes us smile.<br />
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I have been meaning to write a post about what I feel are the contributing factors to Reo's decline, in the hopes that they might help another dog owner out there. I've been putting it off because of my own personal pain - I just wasn't ready. Of course, hindsight is 20/20, and it wasn't until her final weeks that I was able to put all of the pieces together. I still carry a huge burden of guilt for not seeing this sooner and being more proactive about getting her in for blood testing sooner than I did. At the end of the day, she was a nearly 14-year old dog, with several health issues, and we knew we couldn't keep her forever, BUT I am her mama who loves her very much, and it's hard not to blame myself for things related to her health. </div>
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At the beginning of 2014, we reduced her T4 supplementation dosage from 0.1 mg BID to 0.05 mg BID (we did this because she was showing clinical signs of too much thyroid - couldn't keep weight on her despite healthy appetite, restlessness, etc. - and her bloodwork showed her in the upper 50% of the reference range). When we reduced her dose, she seemed to return to normal/stable and so we thought it was the right decision for her. We also made the switch from Medrol to prednisolone liquid, because this was easier for me to adjust her dose when she needed a little more. We were only able to get 4 mg Medrol tablets, and it was too difficult to make adjustments when needed.</div>
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As you might recall, Reo had a dental in July. She had an abscessed tooth along the gumline. We had tried different antibiotics and mouth treatments to get it to abate, but it just wouldn't go away. So, she got a nice cleaning and a few extractions. Her pre-surgery bloodwork looked great, and we had the anesthesiologist custom-tailor a plan for her based on her medical history (as well as monitor her surgery). She was only under for about 45 minutes, and they let me be there and hold her/talk to her for her recovery to help reduce her stress. It was kind of incredible the difference it made in her disposition after the surgery. She was much more happy and energetic, and way more playful, too. I regretted waiting so long (over a year) to get this surgery for her, and wished I did it sooner, because it was clearly bothering her!</div>
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At the end of August, we traveled back to the east coast with Reo and Leigh for my sister's wedding. It was a stressful/busy time for all of us, and that was when we started to notice Reo's waning appetite. She was still eating, just more slowly, was more picky about what she was eating. This went on for weeks - somehow not severe enough for me to bring her to the vet, but somehow not quite right, either. Clinically, she seemed to be doing ok - drinking her normal amount (which was always a fair bit), urine and stools normal to my eyes. She was just slightly "off".</div>
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Around the end of September, I was at the end of my rope with the eating games. She still would eat, but smaller portions, and I was using a rotation to keep her interested. I noticed she was getting up earlier and earlier for a drink of water and/or potty. So finally I made an appointment with my vet for a booster injection of DepoMedrol, an EI-1 panel, and regular bloodwork.</div>
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Nothing could have prepared me for how poor her bloodwork was. Just two months ago, her blood chemistry looked great! Now she was in kidney failure - BUN and creatinine were highly elevated, phosphorus, very high, and electrolytes out of balance. Some liver enzyme elevations, too - but we were mostly concerned about the kidneys. The CBC showed an infection, as well - very high white blood cells. The EI-1 panel came back and her levels were awful - high estrogen, low cortisol, low T3 and T4, and low immunoglobulins. I was hoping that the DepoMedrol injection would perk her up while we could get her infection under control. We also did leptospirosis serology, which came back negative.</div>
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She had a week of IV fluid flush at our vet's - I would drop her off in the morning, and pick her up in the evening - to try and get her BUN down. She had two different antibiotics (which I know did NOT help her appetite because they upset her stomach), as well as Denamarin for her liver. Her appetite was extremely poor, and I tried to get her to eat absolutely anything she would (but tried to keep low phosphorous foods in mind). We were also doing sub-cutaneous fluids at home, to try and keep her hydrated, and to help her body flush out the toxins. I also joined the (incredibly wonderful, helpful, and knowledgable) K9 Kidneys Yahoo Group, who truly helped educate me, in a very short period of time, of everything I needed to do to help Reo's kidneys.</div>
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We had an ultrasound, which confirmed a kidney infection as well as mild pancreatitis (no doubt from letting her eat whatever she would eat over the past couple of weeks). So now I had to find something low fat and low phosphorous that would entice her - not to mention all of her medication. It was nearly impossible! We had an absurd feeding and medication schedule, that occupied my whole day, essentially. She was being fed every two hours, and many of her meds couldn't be given together and had to be spread out. Reo HATED all of this, and started rebelling at all of the meds. So, I began using a syringe to help feed her. I would make organic baby rice cereal, and mix it with beef and veggie dinner baby food and syringe it small amounts at a time, mixed with some of her meds. She would eat this way, but not on her own. I even gave her "dessert" of baby food fruit, mixed with aluminum hydroxide powder to try and mitigate her phosphorous levels. </div>
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There was no doubt we were scrambling, and very far behind, to try and help her. I told her every day that I was paying attention to her, and she had to let me know if/when she was ready to stop fighting. What I feel were contributing factors to Reo's decline: </div>
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1) Reducing T4 dosage without running a re-check EI-1 panel a few months later to see her levels</div>
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2) Switching to prednisolone over Medrol without running a re-check EI-1 panel a few months later to see her levels</div>
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3) Anesthesia from her dental affecting her kidneys (could catheter insertion contributed to her kidney infection?)</div>
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4) Not running a re-check blood chemistry a month or so after her dental, which would have helped us pick up on the infection/kidney failure earlier</div>
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5) Some stressful travel events</div>
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Essentially, this was a "perfect storm" of events, that I feel all together contributed to her decline. How could I have been so blind to not pay attention to all of this together? She was just doing so well with everything until all of a sudden she was not. *kicks self*</div>
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We were repeating blood chemistry and CBC many times to see where she was, and the disturbing thing was that the infection was not going away. Some improvement in BUN and creatinine, but not enough to make her feel better. There was slight improvement in white blood cells, but the infection was still strong, despite two different antibiotics (she was on oral, but we had also done injectables as well). We were using Cerenia to help with her nausea and encourage her appetite. I began to feel like we were fighting a losing battle. </div>
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One morning, I had just syringed Reo's breakfast into her and had her all set up on the couch. I went upstairs to get my coffee, and when I came back, she had thrown everything up everywhere and was just sitting in it, looking like she was in a daze. It was at that precise moment that I knew it was her time. I exploded into tears and lovingly cleaned her up. The fire and spark in her was gone and she didn't want to fight any more.</div>
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We spent a day celebrating her - thanking her, loving her, cuddling her, kissing her. We sang her song, 'Rio" by Duran Duran, and danced around with her. We sat in the sun for hours, in the unseasonably warm October for Denver. I fed her vanilla ice cream. We cried rivers of tears. We laughed at stories we shared of her antics. I fed her more vanilla ice cream. I made an appointment with one of my veterinary friends, who came to our house to help her earn her angel wings. We sent her off with love, gratitude, and comfort. All of our dogs were there with her, and she took her final, shuddering breath laying on my chest. I can still feel the weight of her there, against my heart.</div>
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She was a once-in-a-lifetime dog, and a very special little girl. She is profoundly missed by her family, including her "online extended family" of SARDS dogs and their owners. I will continue SARDS education and group maintenance in her honor! From my family to yours, thank you for your support.</div>
Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com14tag:blogger.com,1999:blog-3941184839667202215.post-79727412930735915422015-01-22T17:20:00.001-08:002015-01-22T17:20:29.178-08:00Still processing...01/22/15 - I can't believe it's been 3 months since Reo has passed. It feels like a lifetime, and my heart is still grieving. <br />
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I have been mulling over my informative blog post to discuss the factors I feel lead to Reo's decline (spoiler alert - the anesthesia from the dental procedure she had in July, together with a few other factors). But, I can't quite bring myself to write it yet. I will not abandon you, dear readers! I know many of you read this blog with interest, and have cared and loved Reo from afar. I just need a little more time to gather my thoughts, and to grieve a bit more. It is amazing how such a tiny dog has left such a large void in my family's lives - human and dog.<br />
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Thank you for your collective patience...bear with this grieving mamma. :)Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com6tag:blogger.com,1999:blog-3941184839667202215.post-55075652560788791542014-11-11T06:53:00.000-08:002014-11-11T06:53:19.857-08:00Reo is an angel now...It's taken me weeks to write this post, and I do have more to say, looking back on the events that transpired over the past several weeks...but for now, just a tribute to her:<br />
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January 03, 2001 ~ October 21, 2014. Today, our beloved Reo earned her angel wings. Jagart's Thalo Vermilion Reo - sassy gal in the show ring, original squirrel patrol, loyal and loving companion all of her days, ghostface killah to her toys, most courageous dog I've ever met. She traveled with us to 28 states, making her more traveled than most Americans, I am sure! She overcame so many health obstacles in her life, never let her blindness stop her from her independence (or from bossing much bigger dogs around!), and in her last years was an inspiration to thousands of dogs and their owners around the world by raising awareness for SARDS (a legacy I will continue in her memory for the years to come). Full of fighting spirit her whole life, she was betrayed by her little old lady body in the end. Her kidneys just could not hold out while we tried to heal the infection and get her endocrine issues back on track.<br />
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Our home feels empty, we have holes in our hearts, and our Leigh is without her lifelong best friend. I miss her so much already - I cannot yet believe she's gone when I still feel her warmth on my chest. Thank you, sweet Reo, for teaching me to be a better person and dog owner. You gave our family so much joy and so many laughs over the years, not to mention valuable dog owner lessons. We are inspired by your strength and courage, and will keep your spirit alive in our hearts and in joyful memories for the rest of our days. I won't be able to sit in the afternoon sun without thinking of how much you loved it.<br />
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In the words of Duran Duran...which is forever "your" song...<br />
"...You know you're something special and you look like you're the best...<br />
Her name is Reo and she dances on the sand<br />
Just like that river twisting through a dusty land<br />
And when she shines she really shows you all she can<br />
Oh Reo, Reo dance across the Rio Grande..."<br />
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Run free, sweet Reo! There are so many squirrels and chips waiting for you on the other side - maybe your sib Mikaela will help you hunt! Don't forget your loving family down here on earth - we'll be reunited again someday - but until then, we'll look for you to visit us in our dreams. All our love, always. Lynn, Sean, Leigh, Tula, and Capone. ♥ ♥ ♥<br />
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<br />Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com5tag:blogger.com,1999:blog-3941184839667202215.post-31040814983354071432014-07-06T08:42:00.001-07:002014-07-06T08:42:30.672-07:00Dental health!07/06/14 - Reo had surgery last week! Eeeek! We had done everything we could to prevent her from undergoing anesthesia, due to her hormonal imbalances, age, and heart murmur. But, she developed a pocket along her gumline that would accumulate food. It bled like crazy when I tried to brush her teeth, and I know it was painful to her. So, we made the decision to get her a thorough dental, to let her live out her days pain-free.<br />
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We are very fortunate to live in the city next door to VCA Alameda East - one of the best vet hospitals in the country. Reo's surgery was detailed, and she had an anesthesiologist on hand to tailor her treatment plan, and monitor her surgery to make sure everything went well. Fortunately for us, it did! She did extremely well, considering the circumstances, and is nearly back to her normal self - what a relief!<br />
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I know that many of us struggle with our dogs' dental health, particularly those of us with little dogs. Reo's oral surgery was done by a Diplomate in dentistry. I told him we have tried just about every dental toothpaste, spray, gel, wipe, and food additive out there (even those prescribed by our general practice vet), but it didn't help or prevent Reo's periodontal disease. I wanted to share a few things he told me, in hopes that it will help someone!<br />
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The first thing he told me is that there is NO substitute for brushing. Our dogs' teeth really need the mechanical action to get plaque off teeth, so don't delude yourself that a miracle product is going to eliminate this need.<br />
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The second thing he said, is that there is only one brand of dental products on the market that is VOHC-approved (Veterinary Oral Health Council - didn't even know there was such a thing!). That brand is Healthymouth: <a href="http://www.healthymouth.com/">http://www.healthymouth.com/</a><br />
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He recommended the water additive, which I purchased (expensive!). It is way too soon to tell if it is effective, but all of the dogs in my household are getting this product in their water, so we shall see if it helps.<br />
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Just wanted to share what I learned! :)Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com2tag:blogger.com,1999:blog-3941184839667202215.post-10483638057349381212014-04-08T06:58:00.002-07:002014-04-08T06:58:56.164-07:00Renal panel - in the clear!<b>04/08/14</b> - Last week, we repeated the renal panel for Reo. It took longer than I had anticipated because she kept having set-backs for a variety of reasons. The big set-back was that our younger rescue puppy went after Reo over a crumb on the floor (hello dog-dog resource guarding issues - I was not expecting you!!). Reo was fine - he just scared her very badly and knocked her over on the floor, poor sweet girl. The stress of the incident brought on a pretty bad flare and she was miserable - lots of diarrhea, depression, inappetance. We are back on track now, but we were very worried about her for a few weeks.<br />
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The good news is, Reo's renal panel looks great! All the electrolytes have normalized, which makes me think that the initial changes we saw were a result of post-seizure activity, and not true kidney disease and/or her adrenal exhaustion/Atypical Addison's condition moving toward "true" Addison's. The only thing slightly elevated was BUN, and we are not worried about that at this time. Yay! Very relieved that we don't have to make any other changes right now.<br />
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Reo seems quite stable for the moment. :)Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com17tag:blogger.com,1999:blog-3941184839667202215.post-18326199362279479052014-03-25T06:35:00.001-07:002014-03-25T06:35:22.735-07:00Prednisolone vs. Medrol<b>03/24/14 </b>- Today I started Reo on PediaPred (5 mg/5ml) prednisolone sodium phosphate, instead of Medrol. The reason? I could only get 4 mg Medrol tablets, and was cutting them into fourths for Reo's daily dose. When she needs to get a little more (and hopefully in the future, a little less), it is hard to add more or less to her dose by using the tablets. The liquid gives us more flexibility to titrate her dose down in the future, and increase during times of stress.Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com0tag:blogger.com,1999:blog-3941184839667202215.post-74294889932915103812014-03-03T09:01:00.002-08:002014-03-03T09:01:28.690-08:00Definite improvement<b>03/03/14 </b>- Well, Reo is doing just wonderfully at present! There have been no more seizures, thankfully.<br />
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After only a couple of days on the reduced thyroid dosage, she was perkier, seemed happier and more active. That trend is continuing, so I am very happy. We will repeat her bloodwork in a couple of weeks and see how she is doing, but I am optimistic!<br />
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With respect to diet, I reduced her Stella & Chewy's portion, and have replaced that with ZiwiPeak tripe recipe canned food. I rotate the canned food with sardines or canned salmon, just to give her some variety. Will see how her kidney panel looks soon and see if she is improving. I would like to get her to gain at least 8 ounces if possible, my skinny girl!Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com2tag:blogger.com,1999:blog-3941184839667202215.post-78965839711923407352014-02-15T08:48:00.004-08:002014-02-15T08:48:56.981-08:00New issues<b>02/15/14</b> - Reo has been having some new issues lately, so wanted to share with everyone. :-/ This is the time of year when Reo always struggles with something. We are about a month away from her SARDS-versary when she was diagnosed. She has a presentation of estrogen spike in a new way each year, which is a little frustrating! (You might remember Levin's assertion that spring is a natural increase in adrenal activity in mammals - us too!, and because many of our dogs can't make cortisol, this results in an estrogen spike, which can manifest in different ways in different dogs.)<br />
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About 2 weeks ago, Reo had a seizure, followed by another one 4 days later. I wasn't home for either, but my husband was (and was terrified, poor guy!). We suspect the stress of me traveling, coupled by -20 degree temperatures was enough stress to put her over the edge (her second seizure happened when she went out to go potty, poor girl!).<br />
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This week, we went in for a check up to the vet - she is neurologically great, whew! Since her last blood chemistry done in January looked great on the liver enzyme side, but showed a little uptick in kidney values, I asked my vet to run a renal panel just to check. Sure enough, she had further increases in kidney values and was now abnormal for BUN, creatinine, sodium, and potassium all elevated (but nothing off the charts). We are not sure if this is "true" renal issues, or if it's changes from post-seizure activity. <br />
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So, we will monitor, and do another renal panel in a month. I will also make a slight change to her diet, and phase out the very high protein Stella & Chewy's patties (45% min protein), and replace with a high-quality canned food (~8% protein) as a topper for the ZiwiPeak dehydrated raw (34% min protein), to see if slightly less protein will ease the load on her kidneys. I refuse to put her on any sort of prescription diet!<br />
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We were also in the process of making some changes to her thyroid dosage (we think she is getting too much thyroid replacement, since her metabolism is super fast and I cannot keep weight on her, even with the high protein/fat food), so we'll have to see how she does with less. Reo was close to 10 lbs when she was diagnosed with SARDS, so we have been treating her at the 10 lb dose for Medrol and thyroid, since it was most convenient. But, she now weighs only 6.5 lbs, so it's possible she's getting more than she needs of both, and we need to find the best dose for her.<br />
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And, just for fun, she has also developed a heart murmur! My vet put it at grade 1-2, so not incredibly serious. When we took x-rays, we saw a slightly enlarged heart, and also a little bit of collapsing trachea. It's hard to know what caused what, or what is just a normal part of aging (she is 13, after all!). We are not doing anything for the heart at this time, and will just monitor.<br />
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I don't want to change too many things at once because we won't know what's made a difference. But, I feel fortunate that my vet loves Reo, is open to new ideas and possibilities, and is willing to do whatever is recommended by Caroline. So, I remain optimistic and grateful! :)Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com0tag:blogger.com,1999:blog-3941184839667202215.post-38437157158458022382014-02-09T07:58:00.000-08:002014-02-09T07:58:37.547-08:00Another SARDS dog's blogI came across another SARDS dog blog today! I'm feeling flattered that it was inspired by Reo's blog, and Shasta's mom is right on in trying to help get out information as much as possible.<br />
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Shasta is a gorgeous GSD/Malamute mix, so she brings some "big dog" perspective to SARDS. Bounce on over to their blog here: <a href="http://sardshastastory.blogspot.com/">http://sardshastastory.blogspot.com/</a> and read their story!<br />
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*Spoiler alert* They were also able to restore vision by following Dr. Plechner's treatment recommendations!Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com0tag:blogger.com,1999:blog-3941184839667202215.post-34031331376827571992014-02-04T13:02:00.000-08:002014-02-04T13:02:35.057-08:00Eighth EI-1 panel resultsAs promised, below is an updated table of Reo's EI-1 panels. I've added the results of her panel at the end of November. <br />
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table.MsoNormalTable
{mso-style-name:"Table Normal";
mso-tstyle-rowband-size:0;
mso-tstyle-colband-size:0;
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font-family:Cambria;
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<table border="0" cellpadding="0" cellspacing="0" class="MsoNormalTable" style="border-collapse: collapse; margin-left: 4.65pt; mso-padding-alt: 0in 5.4pt 0in 5.4pt; mso-yfti-tbllook: 1184; width: 559px;">
<tbody>
<tr style="height: 28.0pt; mso-yfti-firstrow: yes; mso-yfti-irow: 0;">
<td nowrap="" style="border: solid windowtext 1.0pt; height: 28.0pt; mso-border-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 48.0pt;" valign="bottom" width="48">
<div class="MsoNormal">
<br /></div>
</td>
<td style="border-left: none; border: solid windowtext 1.0pt; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">Reference Range<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-left: none; border: solid windowtext 1.0pt; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 60.0pt;" valign="bottom" width="60">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">16-Mar-11<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-left: none; border: solid windowtext 1.0pt; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 57.0pt;" valign="bottom" width="57">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">30-Apr-11<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-left: none; border: solid windowtext 1.0pt; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">15-Jun-11<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-left: none; border: solid windowtext 1.0pt; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">4-Aug-11<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-left: none; border: solid windowtext 1.0pt; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">4-Jan-12<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-left: none; border: solid windowtext 1.0pt; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">25-Jun-12<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-left: none; border: solid windowtext 1.0pt; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 58.0pt;" valign="bottom" width="58">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">10-Dec-12<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-left: none; border: solid windowtext 1.0pt; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 59.0pt;" valign="bottom" width="59">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">22-Nov-13<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 32.0pt; mso-yfti-irow: 1;">
<td style="border-top: none; border: solid windowtext 1.0pt; height: 32.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 48.0pt;" valign="bottom" width="48">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">Total
Estrogen<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 32.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">30 - 35<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 32.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 60.0pt;" valign="bottom" width="60">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.19<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 32.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 57.0pt;" valign="bottom" width="57">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.15<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 32.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.11<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 32.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.06<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 32.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.04<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 32.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.05<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 32.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 58.0pt;" valign="bottom" width="58">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.02<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 32.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 59.0pt;" valign="bottom" width="59">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.03<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 14.0pt; mso-yfti-irow: 2;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 48.0pt;" valign="bottom" width="48">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">Cortisol<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">1.0 - 2.5<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 60.0pt;" valign="bottom" width="60">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">8.43<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 57.0pt;" valign="bottom" width="57">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">7.03<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.97<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.82<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.68<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">1.4<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 58.0pt;" valign="bottom" width="58">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.96<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 59.0pt;" valign="bottom" width="59">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.85<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 14.0pt; mso-yfti-irow: 3;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 48.0pt;" valign="bottom" width="48">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">T3<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">100 - 200<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 60.0pt;" valign="bottom" width="60">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">62.7<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 57.0pt;" valign="bottom" width="57">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">72.12<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">87.92<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">156.94<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">135.29<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">169.94<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 58.0pt;" valign="bottom" width="58">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">157.64<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 59.0pt;" valign="bottom" width="59">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">154.03<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 14.0pt; mso-yfti-irow: 4;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 48.0pt;" valign="bottom" width="48">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">T4<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">2.0 - 4.5<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 60.0pt;" valign="bottom" width="60">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.87<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 57.0pt;" valign="bottom" width="57">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">1.15<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">1.6<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">3.99<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">3.21<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">7.17**<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 58.0pt;" valign="bottom" width="58">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">5<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 59.0pt;" valign="bottom" width="59">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">4.89<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 14.0pt; mso-yfti-irow: 5;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 48.0pt;" valign="bottom" width="48">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">IgA<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">70 - 170<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 60.0pt;" valign="bottom" width="60">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">50<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 57.0pt;" valign="bottom" width="57">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">53<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">57<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">65<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">67<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">66<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 58.0pt;" valign="bottom" width="58">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">68<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 14.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 59.0pt;" valign="bottom" width="59">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">67<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 28.0pt; mso-yfti-irow: 6;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 48.0pt;" valign="bottom" width="48">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">IgG<o:p></o:p></span></div>
</td>
<td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">1,000 - 2,000<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 60.0pt;" valign="bottom" width="60">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">722<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 57.0pt;" valign="bottom" width="57">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">754<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">883<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">946<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 55.0pt;" valign="bottom" width="55">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">973<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 56.0pt;" valign="bottom" width="56">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">970<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 58.0pt;" valign="bottom" width="58">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">992<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 28.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 59.0pt;" valign="bottom" width="59">
<div align="right" class="MsoNormal" style="text-align: right;">
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<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">74<o:p></o:p></span></div>
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<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">97<o:p></o:p></span></div>
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<span style="font-family: Calibri; font-size: 11.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">98<o:p></o:p></span></div>
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<br />
Overall, Reo looks great. No major changes in anything - just the typical slight ups/downs we see over time. She is stable.<br />
<br />
We did a blood chemistry and CBC as well (we do this every 6 months to make sure she is tolerating her medications and is healthy) and her liver values and cholesterol have actually gone down since the summer, which is pretty cool. :)Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com0tag:blogger.com,1999:blog-3941184839667202215.post-72714776912678234122014-01-28T14:30:00.003-08:002014-01-28T14:30:56.164-08:00SARDS Dogs United Facebook groupMy goodness, I am behind in updating! I'm sorry, fair readers. Wishing you and your pups a wonderful New Year!<br />
<br />
Reo is doing very well - I will post her latest bloodwork soon. We had another EI-1 panel done at the end of the year, as well as blood chemistry and CBC. Her blood chemistry was quite notable, with liver values and cholesterol number actually going down since her last test (yay!). Hormone levels are stable, with only slight changes up or down over time.<br />
<br />
Currently her only health "problem" is a potential issue with collapsing trachea. She's always had issues aspirating water when she drinks, but now she's been sneezing/reverse sneezing/coughing at random times. We have her on a course of Clavamox to make sure it's not a simple upper respiratory infection, but so far I haven't noticed any changes.<br />
<br />
The thing that makes me think it is NOT collapsing trachea is because she is not affected when she is walking or exercising. Sort of strange...<br />
<br />
ANYWAY!!!<br />
<br />
My primary reason for writing this post is to alert you all to a new Facebook group that we have created for SARDS dog owners, or those interested in the disease. It is called SARDS Dogs United, and you can request to join us here: <a href="https://www.facebook.com/groups/405209912943724/">SARDS Dogs United</a><br />
<br />
We hope this will be an easy way to keep in touch with other SARDS owners. Now that Yahoo has changed its groups format, it is less user-friendly. Feedback welcomed! :)<br />
<br />Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com2tag:blogger.com,1999:blog-3941184839667202215.post-22805797286273888302013-09-07T07:49:00.000-07:002013-09-07T07:49:51.245-07:00New article discussing the Melan-100 for SARDS screening<b>09/07/13</b> - All is well in our household - I have been busy lately with Miniature Pinscher rescue activities, which is rewarding yet challenging! I will write another post once Reo has her follow-up appointment at the ophthalomologist in a couple of weeks.<br />
<br />
I wanted to post because there is a new article in the Journal of Veterinary Medical Science coming out from a group in Japan that discusses the Melan-100 colorimetric PLR device that is often used by ophthalmologists to help diagnose SARDS, PRA, and other eye diseases.<br />
<br />
This is the abstract:<br />
<br />
<i>To determine the efficacy of a colorimetric pupil light reflex (PLR) device (Melan-100®, U.S.A.) in dogs of sudden acquired retinal degeneration syndrome (SARDS; 16 cases), progressive retinal atrophy (PRA; 10 cases) and optic pathway disease (6 cases). The colorimetric device detected PLR abnormality in 32, 16, and 9 eyes with SARDS, PRA and optic pathway disease, respectively, whereas white light detected PLR abnormality in 18, 11 and 9 eyes with SARDS, PRA and optic pathway disease, respectively. SARDS dogs displayed miosis, while optic pathway disease dogs displayed mydriasis by blue light examination. Thus, colorimetric PLR may be a useful method for determining whether electroretinography (ERG) or magnetic resonance imaging (MRI) should be performed for dogs with acute blindness.</i><br />
<br />
The full text of the article is available (though because it is a pre-print copy, it does not look as pretty as a published article - there are line numbers in the left margin) at this link: <a href="https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_12-0363/_pdf"> https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_12-0363/_pdf</a><br />
<br />
It looks like the authors agree that an ERG is very important for accurately diagnosing SARDS:<br />
<br />
"Although the colorimetric PLR device is useful as a screening test, it is risky to diagnose these abnormalities with this method alone. It is necessary to diagnose SARDS, PRA, and optic pathway disease via funduscopic examination, ERG, and MRI."Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com10tag:blogger.com,1999:blog-3941184839667202215.post-48638079023602367242013-07-24T06:36:00.001-07:002013-07-24T06:36:25.519-07:00Ophthalmologist visit<b>07/24/13</b> - We went to an ophthalmologist on Monday for Reo. She has been having some issues with her right eye for the past few months, and our regular vet couldn't figure out what was wrong. We tried some eye drops, an antibiotic, and did fluorescein staining - all either didn't help or show anything that could give us a diagnosis.<br />
<br />
Her symptoms have been - "swollen" eye appearance, she is not opening her eye fully and the lower eyelid is droopy; very red white of her eye; some clear discharge; occasional itching; white cloudy area appearing in the cornea (not a cataract).<br />
<br />
I *loved* this ophtho, as compared to the one in KY that diagnosed Reo's SARDS. He was fascinated by her case, and we are the first ones to have treated endocrine issues in SARDS that he's met. He was surprised by how good her blood chemistries looked, after being on long-term Medrol. I was careful to point out that the Medrol is not a *therapy*, it's only replacing what she can't make<br />
naturally. We talked a lot about our experience and what we did for Reo's treatment.<br />
<br />
He did a very thorough exam, and said that Reo's retinas were unlike any he's ever seen before in a SARDS dog, even 2.5 years later. She had a lot of weird stuff going on, apparently! That's my Reo...<br />
<br />
After his exam, he pointed out Reo had a slight head tilt to the right, which I could see after he mentioned it. I think she has always walked like that since her diagnosis, and I didn't really think anything of it. He suspected Horner's syndrome, which is another "mystery". But essentially, one of the nerves is damaged and/or not firing properly, which leads dogs to have eye appearance<br />
issues. He thought that because she wasn't using that eye regularly, there was a nerve atrophy of sorts. There is a very simple test used to diagnose this - he put a drop of norepinepherine in her eye. In 15 minutes, she was back to normal eye appearance! That was pretty cool.<br />
<br />
He said that because this test is so reliable and a strong positive, there is almost no chance that it could be something more serious (i.e., a brain tumor) that is causing this issue. So, it was a huge relief to me. He mentioned that the redness of her eyeball is also an indication of lack of vascular tone in the<br />
eye due to the Horner's (this might be of interest to some on this list, whose dogs experience very red eyes!). Anyway, there is no "treatment" for Horner's, and he said that most dogs spontaneously correct in a few months - interesting.<br />
<br />
Finally, another tidbit he gave me was concerning minerals and lipemia. For the past 1.5 years (since we moved back to Colorado), Reo has had very lipemic blood (lipemic means fat in the blood, which can skew some blood test results). Our regular vet never really said it was a problem, since Reo's cholesterol and triglycerides are normal.<br />
<br />
The ophtho said that he could see the lipemia in Reo's eyes, and that she should be on a low-fat diet immediately. I told him there was no chance that I was changing her diet to low fat as she is quite healthy and we do blood chemistries 2x/year to make sure. Also, she has never had pancreas issues - all levels are normal.<br />
<br />
He said he wanted to try her on EDTA drops, which will chelate/pull out extra minerals that are in Reo's eye. I asked him if mineral supplementation could cause lipemia - he said most definitely. Reo has been on the Nutramin mineral supplement, suggested by Dr. Plechner, for 2.5 years, so I wondered if it was causing an issue and leading to Reo's lipemia (maybe she just doesn't need the<br />
supplement any more!). Previously, she was getting the Nutramin 2x/day, and I've dropped down to 1x/day for the time being. Will see how she does, and I will consider completely eliminating it in the future.<br />
<br />
*Note - I can't find anything online concerning mineral supplementation causing lipemia in dogs, and not much reliable info in humans. I'll keep searching, and also ask my regular vet. Because the ophtho was so emphatic, it seems weird to me that my vet never said anything about the lipemia, or the supplementation maybe causing it.<br />
<br />
We came home with EDTA drops, and cyclosporine ointment, and a re-check in 6 weeks to see how she does. Stay tuned! :)Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com5tag:blogger.com,1999:blog-3941184839667202215.post-86643633380183390342013-07-03T07:03:00.000-07:002013-07-03T07:03:06.921-07:00Post-vacation trip to the ophthalmologist<b>07/03/13</b> - We had a glorious time in Europe for nearly 3 weeks!<br />
<br />
Reo (and all the pups) did great under my brother's care - everyone was happy and healthy when we got back, and there was much rejoicing as we were reunited.<br />
<br />
But, Reo has been having some issues with her right eye for a couple of months. We've tried a few different things (drops, allergy meds, etc.) but nothing seems to be working. Right around the time she was diagnosed with SARDS 2 years ago, she walked into a tree and scratched her cornea. She's has the scratch since then and it never caused any issue. But now, it seems to have a secondary whitish mark that is coming out from the scratch. Our regular vet did a fluorescein stain and it didn't uptake anything (good), and it's not anything like a cataract (good), but we can't figure out what is going on.<br />
<br />
I decided to make an ophtho appointment to see if there is anything that can be done. It's clear that the eye is itching her, and the white of her eye is quite red. It also looks like the lower eyelid is a bit swollen. So, since our regular vet can't solve the puzzle, and Reo is not getting better on that front, we're going to go and get it checked out.<br />
<br />
Fingers crossed we can get an appointment fairly soon and get to the bottom of it! Stay tuned...Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com0tag:blogger.com,1999:blog-3941184839667202215.post-7719498750858314172013-06-12T11:44:00.003-07:002013-06-12T11:44:29.246-07:00Headed overseas<b>06/12/13</b> - Tomorrow, Sean and I are headed to Europe for 3 weeks, sans dogs! My brother is watching over our house and pack, which means I'll be separated from Reo for the first time in quite a while!! We will have my brother pulse her Medrol dose for the first week we're gone, to hopefully help mitigate her stress.<br />
<br />
She has been doing pretty well lately, but allergies are bugging her. I have her on Claritin based on my vet's recommendation, though I don't think it's helping her. She has an itchy/watery right eye, that has been bugging her for over a month. The vet's looked at it, did fluorescin testing, and even gave her some NP Dex eyedrops to try for a week (which didn't help). So, I think we'll go to the ophthalmologist when we get back, just to be on the safe side.<br />
<br />
Anyway, fingers crossed all goes well and there are no issues with little miss high-maintenance. :)<br />
<br />
À bientôt, fair readers!<br />
<br />Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com0tag:blogger.com,1999:blog-3941184839667202215.post-83810824700915583962013-05-22T14:29:00.004-07:002013-05-22T14:29:49.065-07:00Tooth problems be gone!<br />
<b>05/22/13</b> - I went to the vet last Friday, and she said she *really* does not want to put Reo under anesthesia to clean her teeth (whew!!). But, that she has seen good success "pulsing" dogs with dental issues with clindamycin hydrochloride. She thought that with Reo's lowered immune system, her body had a hard time keeping the plaque bacteria at bay. So she has her on a low dose 2x a day until gone (I<br />
think it will be about a 7-10 day course, given how much we've used already).<br />
<br />
I've kept up with the Leba III spray, but haven't brushed because I wanted that little lesion to heal. Well I'll be darned...her mouth looks pretty darn awesome, to my surprise! The lesion has healed and is not painful to her anymore, and she doesn't have nearly as much plaque as she did a few days ago.<br />
<br />
So, I'm considering doing this quarterly as "pulse" therapy like my vet suggested. Though I'm not a fan of regular antibiotic use, it might be worth it to prevent anesthesia for dental cleanings/extractions in the future.<br />
<br />
The other interesting side effect is that she is way more perky than she has been before, which could be just because she was in pain before and isn't any more...but it's also making me wonder about dogs that are on the doxy/pred protocol and give antibiotics with cortisol replacement. I remember one of my SARDS friends saying that her dog did great on doxycycline and Medrol, but that most vets don't know why it helps SARDS dogs. Hmmm.<br />
<br />
I also got a chemistry/CBC panel while we were there. I decided not to do an EI-1 panel this June, and switch to yearly in December, instead of bi-annually. I did get a T3/T4 add on, though, just to make sure thyroid was doing ok. Everything looked good, except for elevated ALP and GGT, and elevated cholesterol. Because she has been normal for over a year in these 3 areas, I'm not too worried (we took blood only a half hour after breakfast, and this could have an effect on her numbers). We will repeat a more focused chemistry in July when we get back from vacation and see how she is doing.<br />
<div>
<br /></div>
Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com0tag:blogger.com,1999:blog-3941184839667202215.post-14256496404107755062013-05-16T13:16:00.000-07:002013-05-16T13:16:11.095-07:00Tooth problems<b>05/16/13</b> - Since Reo was diagnosed with SARDS, I haven't put her under anesthesia for anything. But, she has this little lesion on her gumline along one of her back molars that continues to not heal, and I think the tooth might have to come out. Before we got Reo, she had many of her teeth removed due to dental disease, and it has been a struggle to keep her teeth clean (missing many teeth means that she doesn't get good chewing action to keep the plaque at bay). <br />
<br />
I use the Leba III product, and brush her teeth with water once a week, and sometimes scale them if there is a good bit of plaque, but it is not doing the job on this one particular tooth any more, it seems. Leba III is great, but if you forget to spray it one day, it seems like it really makes a difference!<br />
<br />
So, I'm going to take her in tomorrow for the vet to look at her gum. I am hoping that she'll give me some antibiotics and the tooth won't have to come out...but I fear the worst. :( I really don't want to have to put her under anesthesia, but we might not have a choice.<br />
<br />
Poor little thing!<br />
<br />
Her allergies are finally getting under control. She has had a puffy, weepy eye for about 2 months, and she was sneezing for a solid month. Glad that she is feeling better. I'm fortunate that I don't have allergies, but many friends have been suffering extra this spring.Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com0tag:blogger.com,1999:blog-3941184839667202215.post-21085031712753524772013-04-08T08:30:00.002-07:002013-04-08T08:30:39.233-07:00March Madness<b>04/08/13</b> - It's official. March is not Reo's best month. It seems every year in March, we have something going on with her. In my last post, I mentioned her allergy symptoms - sneezing, watery eye (just one eye), general mopeyness). The allergy symptoms continue, though more mild than before. She's also had some GI upset lately. Overall, she's doing fine, but definitely a little outside of "normal".<div>
<br /></div>
<div>
So, 3 Marches of weirdness in a row can't be a coincidence. It makes me think about Caroline Levin's assertion that spring and fall are normal periods of increased adrenal activity. It certainly makes sense in Reo's case, though she seems to make it through fall with no problems. I guess I'll make sure to be extra aware come spring next year, and make sure I'm ready for some bumps in the road!</div>
Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com5tag:blogger.com,1999:blog-3941184839667202215.post-19481938779874791902013-03-05T12:31:00.001-08:002013-03-05T12:31:10.070-08:002 year anniversary<b>03/05/13 </b>- Today marks 2 years since Reo lost her vision (though we're a little ahead of her actual diagnosis)! It seems like it's been far longer than that, to be honest! We have learned so much in the past 2 years. Every day, I am thankful that Reo is still with us, and healthy! I'm so proud of this little dog, I tell you.<br />
<br />
This is a busy time of year for SARDS diagnoses, and I've noticed that Reo has some allergy symptoms (itchy eye, some sneezing). We've had an unusually mild winter in Denver, and I think that there are already some allergens in the air. I'm pulsing her Medrol dose this week to try and help her overcome this.Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com1tag:blogger.com,1999:blog-3941184839667202215.post-70973856965352784972013-02-19T18:57:00.000-08:002013-02-19T18:59:17.735-08:00New(ish) post from Dr. Plechner on SARDS<b>02/19/13</b><br />
<br />
Hope everyone is doing well! We are all great, here, including Ms. Reo, who is as sassy as ever! I recently went on a vacation and left the dogs with Sean - I was nervous, as I hadn't left Reo in nearly a year! I'm happy to report that she did GREAT, and Sean did a wonderful job keeping to her schedule and meal regimen. :)<br />
<br />
Dr. Plechner has re-worked his website. Though it looks nicer, a lot of his resources are missing, which makes me sad.<br />
<br />
He has written a few new articles on SARDS, for your consideration:<br />
<br />
Three case studies:<br />
<a href="http://drplechner.com/learn/specific-diseases/sards-clinical-case-studies/">http://drplechner.com/learn/specific-diseases/sards-clinical-case-studies/</a><br />
<br />
Overview:<br />
<a href="http://drplechner.com/learn/specific-diseases/sards/">http://drplechner.com/learn/specific-diseases/sards/</a><br />
<br />
As you might remember, my own personal opinion is that Caroline Levin knows so much about treating SARDS specifically, and her recommendations for retinal protection supplements can be of great help to newly-diagnosed SARDS dogs. Her treatment is based off of Dr. Plechner's ideas. For Reo, I felt that a combination of Levin's and Plechner's treatment suggestions were the very best choice for Reo, and helped restore her vision in 5 months. If I had to go back, I would do the same treatment (albeit much more quickly).Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com2tag:blogger.com,1999:blog-3941184839667202215.post-2957205957993472312013-01-03T20:49:00.003-08:002013-01-03T20:49:26.954-08:00Seventh EI-1 results (and happy birthday!!)<br />
<b>01/03/12</b> -<br />
<b><span style="color: magenta; font-size: large;"><br /></span></b>
<b><span style="color: magenta; font-size: large;">Wishing my sweet Reo a very happy 12th birthday!! :)</span></b><br />
<br />
I get a little overwhelmed each birthday since her SARDS diagnosis, as I'm so thankful that she is with us, and there were so many times I thought she wouldn't make it to 11, let alone 12! :) She got some dehydrated lobster meat treats (made by Bravo) today for her birthday. Boy, did she LOVE those!!<br />
<br />
Over the holiday week, I got Reo's EI-1 panel results back from NVDS. The results are added to her master table in the far right column.<br />
<br />
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Estrogen<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 1.0in;" valign="bottom" width="72">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">30 - 35<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: .75in;" valign="bottom" width="54">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.19<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.15<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.11<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.06<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.04<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.05<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">35.02<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 15.0pt; mso-yfti-irow: 2;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 72.75pt;" valign="bottom" width="73">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">Cortisol<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 1.0in;" valign="bottom" width="72">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">1.0 - 2.5<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: .75in;" valign="bottom" width="54">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">8.43<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">7.03<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.97<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.82<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.68<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">1.4<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.96<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 15.0pt; mso-yfti-irow: 3;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 72.75pt;" valign="bottom" width="73">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">T3<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 1.0in;" valign="bottom" width="72">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">100 - 200<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: .75in;" valign="bottom" width="54">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">62.7<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">72.12<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">87.92<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">156.94<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">135.29<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">169.94<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">157.64<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 15.0pt; mso-yfti-irow: 4;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 72.75pt;" valign="bottom" width="73">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">T4<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 1.0in;" valign="bottom" width="72">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">2.0 - 4.5<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: .75in;" valign="bottom" width="54">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">0.87<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">1.15<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">1.6<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">3.99<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">3.21<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">7.17**<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">5<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 15.0pt; mso-yfti-irow: 5;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 72.75pt;" valign="bottom" width="73">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">IgA<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 1.0in;" valign="bottom" width="72">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">70 - 170<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: .75in;" valign="bottom" width="54">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">50<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">53<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">57<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">65<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">67<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">66<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">68<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 15.0pt; mso-yfti-irow: 6;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 72.75pt;" valign="bottom" width="73">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">IgG<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 1.0in;" valign="bottom" width="72">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">1,000 - 2,000<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: .75in;" valign="bottom" width="54">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">722<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">754<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">883<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">946<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">973<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">970<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">992<o:p></o:p></span></div>
</td>
</tr>
<tr style="height: 15.0pt; mso-yfti-irow: 7; mso-yfti-lastrow: yes;">
<td nowrap="" style="border-top: none; border: solid windowtext 1.0pt; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 72.75pt;" valign="bottom" width="73">
<div class="MsoNormal">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">IgM<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 1.0in;" valign="bottom" width="72">
<div align="center" class="MsoNormal" style="text-align: center;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">100 - 200<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: .75in;" valign="bottom" width="54">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">74<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">76<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">87<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">97<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 45.0pt;" valign="bottom" width="45">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">97<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">97<o:p></o:p></span></div>
</td>
<td nowrap="" style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; height: 15.0pt; mso-border-bottom-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt; padding: 0in 5.4pt 0in 5.4pt; width: 49.5pt;" valign="bottom" width="50">
<div align="right" class="MsoNormal" style="text-align: right;">
<span style="font-family: Calibri; font-size: 10.0pt; mso-bidi-font-family: "Times New Roman"; mso-fareast-font-family: "Times New Roman";">98<o:p></o:p></span></div>
</td>
</tr>
</tbody></table>
<!--EndFragment--><br />
<br />
<br />
Overall, I am <u>really</u> happy with how it looks! Her total estrogen is the lowest it's ever been (great!), and her immunoglobulins are the highest they've ever been.<br />
<br />
Cortisol is slightly below normal (but doesn't seem to be anything to worry about, given her erratic cortisol levels in the past), and T4 is slightly elevated. But, T3 is in the normal range, so the vet is not worried about the high T4. Her previous high number in June of T4 was due to a course of Clavamox she was on.<br />
<br />
Both Caroline Levin and Dr. Plechner have suggested that Reo doesn't need blood testing since she's "stable", and we should only do a panel if she seems like she's off track. I'll admit that it's like a crutch for me, to have a snapshot of how she's doing every 6 months. I'll see if I can limit myself to one EI-1 panel per year! I still plan to get a CBC and chemistry panel and thyroid test every 6 months, however, because I feel it's very important to keep track of these values as she is a dog on long-term Medrol.<br />
<br />
That's the update from here. Happy New Year to all!<br />
Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com4tag:blogger.com,1999:blog-3941184839667202215.post-49485566316235517322012-12-21T15:48:00.002-08:002012-12-21T15:48:27.032-08:00Waiting for EI-1 results<b>12/21/12</b> - Still waiting for Reo's bloodwork to come back from NVDS. Apparently, their equipment is down and waiting to be repaired. With the holiday, they think results will come toward the end of next week. Sooooo, we are being patient.<br />
<br />
Reo has been doing very well this week - in a great mood, killing toys. :) She probably feels the lightness of our household, too, as we look forward for some time off! Lots of cuddles and walks in the dogs' future (not that they don't get those every day, but just a little more than normal!).<br />
<br />
Special shout-out today to our other Min Pin, Leigh, who turns 12 today!!<br />
<br />
Wishing all of my readers a very happy holiday season, with health and happiness to come in the new year! <br />
<br />Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com1tag:blogger.com,1999:blog-3941184839667202215.post-90939915736383347502012-12-14T13:07:00.002-08:002012-12-14T13:07:59.803-08:00Diabetes-free!<b>12/14/12</b> - I'm very VERY happy to report that Reo does NOT have diabetes! We went into the vet this morning for a fasted blood draw and urinalysis - both came back negative. HURRAY! <br />
<br />
I was initially concerned that perhaps her adrenal glands kicked in a little bit, and that she had too much cortisol in her system, leading to high blood sugar, but this does not seem to be the case (will wait for the EI-1 panel results next week). Though, I was definitely miffed that she was not displaying any symptoms of diabetes.<br />
<br />
My current theory for the high blood sugar on Monday was the stress of the vet visit. Because Reo was the second dog to go back for a blood draw, perhaps this was enough time for her to have a little adrenaline rush/blood sugar release, which caused the high glucose reading.Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com0tag:blogger.com,1999:blog-3941184839667202215.post-45388299317487541782012-12-12T10:35:00.001-08:002012-12-12T10:35:10.537-08:00Bloodwork, and possible diabetes?12/12/12 - I couldn't resist updating the blog on this date, could I? :)<br />
<br />
On Monday, I took all of the dogs in for their annual exams and bloodwork. Having 3 senior ladies means keeping check of health on the inside, even though everyone looks healthy on the outside!<br />
<br />
Reo got blood taken for both an EI-1 panel from NVDS, as well as regular chemistry/CBC. Apparently, the nurses took too much blood too quickly - Reo passed out right after the blood draw! It was super scary at first, but they gave her some oxygen and she perked right back up. The vet likened it to standing up too quickly and getting lightheaded. That's never happened before, so we'll have to be more careful on blood draws next time!<br />
<br />
Though we need to wait until next week on the EI-1 panel, we already got the chemistry results back. First of all, Reo's blood remains lipemic (fatty). It has been this way for the past year or so, and I wasn't too surprised, but it does affect the CBC portion of the results. Her cholesterol is normal. <br />
<br />
She had very slight elevations in two liver enzymes, ALT and ALP. Because they are very mild, the vet is not concerned, especially as she has been on long-term Medrol. However, her blood glucose was very elevated (377!), and our vet is concerned that Reo could have diabetes. :( Though she was 7 hours post-meal, we will do a fasting blood glucose, and possibly a fructosamine test as well, to see where we stand. At the same time, we will do a urinalysis and urine culture to see where we stand there.<br />
<br />
The strange part is, Reo is not drinking or urinating more frequently. She does not have accidents in the house. She has not gained any weight (in fact, she lost a bit since our appointment in June), and is not more hungry. We keep a close eye on her PU/PP/PD, given our experiences in the past. Reo is also on grain-free, low-glycemic dehydrated/freeze-dried raw food.<br />
<br />
First, cortisol is insulin's counter point. As insulin LOWERS blood sugar, cortisol INCREASES blood sugar. This is important to remember. Many Cushingoid dogs (high cortisol) also have diabetes - I think about 20% of dogs who are Cushingoid also have diabetes.<br />
<br />
I have been thinking a lot (I know my readers are surprised!) about what could have brought this on. In the past few months, I discontinued Reo's phosphatidyl serine supplement. Phosphatidyl serine is thought to blunt the cortisol response/spikes in cortisol. It's possible that my giving her PS was reducing the amount of circulating cortisol in Reo's body, and when I stopped giving this supplement, she had an increase in cortisol, resulting in an increase in blood sugar (this will become apparent when we get the EI-1 panel results back - if her cortisol is high, perhaps this is the case).<br />
<br />
For the past couple of years, I have been operating under the assumption that Reo has very, very little adrenal function (if at all). However, perhaps her adrenals can make a bit of cortisol, and her daily dose is giving her a bit too much. We may need to adjust the dose of her Medrol. I plan to wait and see what the repeat blood tests say, and then I will contact Dr. Plechner and see if any adjustments need to be made.<br />
<br />
Reo, our little problem child! The great news is that she is happy, healthy, and not displaying any "symptoms". I hope the glucose reading was a fluke somehow, and she is not diabetic. I can't imagine having to stick her twice per day, although of course we are totally committed to her for life! <3<br />
<br />
<br />Lynn L.http://www.blogger.com/profile/04983651791041177140noreply@blogger.com0